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22-99 I consider small pairs, TT/JJ/QQ are raising hands, but often terrible candidates for a reraise vs bad competition. You will often reraise with these hands and then a guy who can't fold A8o spikes an ace on you..so it's very rarely correct to put in a third raise and be all-in with one of these hands.

if you're 9-handed and no one has entered the pot, if you're in seat 7, 8, or 9, then you should look at an opening raise as a steal or the foundation of a bluff more than anything.

if you have a tight reputation and raise with 55 in the cut-off seat and then the flop comes A-rag-rag, you can generally buy the pot there versus a sole blind. your raise with 55 could be made with 4-9 offsuit, just as well, though.

JoJo's right about thinning the field, mathmatically speaking, you only hit a set 1 in 8 times you are dealt them, I believe. Why drive out people who can't fold top or middle pair after the flop? You want to hit a set in a multiway flop, not a heads-up pot. You will very rarely get a dream flop of AJ6 with 66 vs AK, so there's more reason to see a cheap flop with a baby pair in multiway action, than heads-up play. With a larger field, the odds increase that someone else hits the flop hard.